Combine Orange Skunk with Jack's Cleanerand Space Queen, and you get Agent Orange – no, not the Vietnam-era pesticide, but rather the medical marijuana strain. Agent Orange also known as “Agent O,” a sativa-dominant hybrid with a 75:25 sativa/indica ratio, Agent Orange produces an uplifting cerebral high ideal for depression, anxiety, and migraines. It can be useful in treating minor aches and pains, but it isn't recommended for treatment of chronic pain.